Drop the files in your game, and click trainer launcher and that will activate your trainer and game.
You have to click the trainer launcher. Let it do its thing then when in game press back and start (Usually is) at the same time and trainer will pop up.
i had the iso. yeah i got the link to all the iso files up to 300 games i downloaded rdr on my flash drive and loaded from there. i justmade a folder and put all the files plus the two xexs in it now im transferring to the neighborhood now