A real nooby question about loading trainers

Can you load Game Trainers when the game is (.ISO format/.GOD format) or do i need to get all the files from the .ISO to load up trainers i have been looked for about 3 days and every topic i see does not say anything about them having to be loaded in a certain (game format)

So is it possible to load a game trainer when the game is (.GOD/.ISO)

and thank you for the help

 

thank you for the is there a topic on how to load trainers in any game format ??